Ontology highlight
ABSTRACT:
SUBMITTER: Han WM
PROVIDER: S-EPMC4805445 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Han Woojin M WM Heo Su-Jin SJ Driscoll Tristan P TP Delucca John F JF McLeod Claire M CM Smith Lachlan J LJ Duncan Randall L RL Mauck Robert L RL Elliott Dawn M DM
Nature materials 20160104 4
Treatment strategies to address pathologies of fibrocartilaginous tissue are in part limited by an incomplete understanding of structure-function relationships in these load-bearing tissues. There is therefore a pressing need to develop micro-engineered tissue platforms that can recreate the highly inhomogeneous tissue microstructures that are known to influence mechanotransductive processes in normal and diseased tissue. Here, we report the quantification of proteoglycan-rich microdomains in de ...[more]