Projection-Specific Visual Feature Encoding by Layer 5 Cortical Subnetworks.

ABSTRACT: Primary neocortical sensory areas act as central hubs, distributing afferent information to numerous cortical and subcortical structures. However, it remains unclear whether each downstream target receives a distinct version of sensory information. We used in vivo calcium imaging combined with retrograde tracing to monitor visual response properties of three distinct subpopulations of projection neurons in primary visual cortex. Although there is overlap across the groups, on average, corticotectal (CT) cells exhibit lower contrast thresholds and broader tuning for orientation and spatial frequency in comparison to corticostriatal (CS) cells, whereas corticocortical (CC) cells have intermediate properties. Noise correlational analyses support the hypothesis that CT cells integrate informat

SUBMITTER: Lur G 

PROVIDER: S-EPMC4805451 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature