Complications and Safety of Preconception Low-Dose Aspirin Among Women With Prior Pregnancy Losses.

ABSTRACT:

Objective

To evaluate complications and safety of preconception low-dose aspirin in 1,228 U.S. women (2007-2011).

Methods

Evaluation of the safety of low-dose aspirin in the participants and their fetuses was a planned secondary analysis of the Effects of Aspirin in Gestation and Reproduction trial, a multicenter, block-randomized, double-blind, placebo-controlled trial investigating the effect of low-dose aspirin on the incidence of live birth. Women aged 18-40 years with a history of one to two pregnancy losses trying to conceive were randomized to daily low-dose aspirin (81 mg, n=615) or placebo (n=613) and were followed for up to six menstrual cycles or through gestation if they became pregnant. Emergency care visits and possible aspirin-related symptoms were assessed at

SUBMITTER: Ahrens KA 

PROVIDER: S-EPMC4805457 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature