Cadmium overkill: autophagy, apoptosis and necrosis signalling in endothelial cells exposed to cadmium.

ABSTRACT: Apoptosis, necrosis, or autophagy-it is the mode of cell demise that defines the response of surrounding cells and organs. In case of one of the most toxic substances known to date, cadmium (Cd), and despite a large number of studies, the mode of cell death induced is still unclear. As there exists conflicting data as to which cell death mode is induced by Cd both across various cell types and within a single one, we chose to analyse Cd-induced cell death in primary human endothelial cells by investigating all possibilities that a cell faces in undergoing cell death. Our results indicate that Cd-induced death signalling starts with the causation of DNA damage and a cytosolic calcium flux. These two events lead to an apoptosis signalling-related mitochondrial membrane depolarisation and a c

SUBMITTER: Messner B 

PROVIDER: S-EPMC4805700 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature