Association between rs1761667 polymorphism of CD36 gene and risk of coronary atherosclerosis in Egyptian population.

ABSTRACT:

Background

Recent studies have demonstrated that CD36 is involved in the progression of atherosclerosis. Associations between rs1761667 polymorphisms of the CD36 gene and susceptibility to coronary artery disease (CAD) are not obvious.

Methods

We studied the relationship between single nucleotide polymorphisms (SNPs), rs1761667 of CD36 gene and the risk of coronary atherosclerosis in a case-control study composed of 71 CAD patients and 76 healthy controls by assessment of allele frequencies and genotype distributions using real-time polymerase chain reaction (PCR) and the allele discrimination technique. Additionally, we detected CD36 expression by flow cytometry.

Results

The distribution of rs1761667 genotypes between the two groups was significantly different (P<0.0

SUBMITTER: Boghdady A 

PROVIDER: S-EPMC4805761 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature