Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis.

ABSTRACT:

Background

Increased circulating plasma urate concentration is associated with an increased risk of coronary heart disease, but the extent of any causative effect of urate on risk of coronary heart disease is still unclear. In this study, we aimed to clarify any causal role of urate on coronary heart disease risk using Mendelian randomisation analysis.

Methods

We first did a fixed-effects meta-analysis of the observational association of plasma urate and risk of coronary heart disease. We then used a conventional Mendelian randomisation approach to investigate the causal relevance using a genetic instrument based on 31 urate-associated single nucleotide polymorphisms (SNPs). To account for potential pleiotropic associations of certain SNPs with risk factors other than urate,

SUBMITTER: White J 

PROVIDER: S-EPMC4805857 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature