Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan.

ABSTRACT:

Aim

To evaluate the effects of OGG1 (Ser326Cys, 11657A/G, and Arg154His) and APE1 (Asp148Glu, and T-656G) polymorphisms on colorectal cancer (CRC) risk.

Methods

We enrolled 727 cases newly diagnosed with colorectal adenocarcinoma and 736 age- and sex-matched healthy controls from a medical center in Taiwan. Genomic DNA isolated from the buffy coat was used for genotyping through polymerase chain reaction. Unconditional logistic regressions were used for calculating ORs and 95%CIs to determine the association between the genetic polymorphisms and CRC risk. Haplotype frequencies were estimated using PHASE software. Moreover, stratification analyses on the basis of sex, age at diagnosis, and tumor subsite and stage were performed.

Results

The CRC risk was higher in patie

SUBMITTER: Lai CY 

PROVIDER: S-EPMC4806195 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature