Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis.

ABSTRACT:

Aim

To investigate the relationship between osteopontin plasma concentrations and the severity of portal hypertension and to assess osteopontin prognostic value.

Methods

A cohort of 154 patients with confirmed liver cirrhosis (112 ethylic, 108 men, age 34-72 years) were enrolled in the study. Hepatic venous pressure gradient (HVPG) measurement and laboratory and ultrasound examinations were carried out for all patients. HVPG was measured using a standard catheterization method with the balloon wedge technique. Osteopontin was measured using the enzyme-linked immunosorbent assay (ELISA) method in plasma. Patients were followed up with a specific focus on mortality. The control group consisted of 137 healthy age- and sex- matched individuals.

Results

The mean value of H

SUBMITTER: Bruha R 

PROVIDER: S-EPMC4806202 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature