MRI visual rating scales in the diagnosis of dementia: evaluation in 184 post-mortem confirmed cases.

ABSTRACT: Accurately distinguishing between different degenerative dementias during life is challenging but increasingly important with the prospect of disease-modifying therapies. Molecular biomarkers of dementia pathology are becoming available, but are not widely used in clinical practice. Conversely, structural neuroimaging is recommended in the evaluation of cognitive impairment. Visual assessment remains the primary method of scan interpretation, but in the absence of a structured approach, diagnostically relevant information may be under-utilized. This definitive, multi-centre study uses post-mortem confirmed cases as the gold standard to: (i) assess the reliability of six visual rating scales; (ii) determine their associated pattern of atrophy; (iii) compare their diagnostic value with exper

SUBMITTER: Harper L 

PROVIDER: S-EPMC4806219 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature