MiR-isomiRExp: a web-server for the analysis of expression of miRNA at the miRNA/isomiR levels.

ABSTRACT: MicroRNA (miRNA) locus has been found that can generate a series of varied isomiR sequences. Most studies always focus on determining miRNA level, however, the canonical miRNA sequence is only a specific member in the multiple isomiRs. Some studies have shown that isomiR sequences play versatile roles in biological progress, and the analysis and research should be simultaneously performed at the miRNA/isomiR levels. Based on the biological characteristics of miRNA and isomiR, we developed miR-isomiRExp to analyze expression pattern of miRNA at the miRNA/isomiR levels, provide insights into tracking miRNA/isomiR maturation and processing mechanisms, and reveal functional characteristics of miRNA/isomiR. Simultaneously, we also performed expression analysis of specific human diseases using p

SUBMITTER: Guo L 

PROVIDER: S-EPMC4806314 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature