Simulated Raman correlation spectroscopy for quantifying nucleic acid-silver composites.

ABSTRACT: Plasmonic devices are of great interest due to their ability to confine light to the nanoscale level and dramatically increase the intensity of the electromagnetic field, functioning as high performance platforms for Raman signal enhancement. While Raman spectroscopy has been proposed as a tool to identify the preferential binding sites and adsorption configurations of molecules to nanoparticles, the results have been limited by the assumption that a single binding site is responsible for molecular adsorption. Here, we develop the simulated Raman correlation spectroscopy (SRCS) process to determine which binding sites of a molecule preferentially bind to a plasmonic material and in what capacity. We apply the method to the case of nucleic acids binding to silver, discovering that multiple

SUBMITTER: Freeman LM 

PROVIDER: S-EPMC4806353 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature