Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia.

ABSTRACT:

Background

Microglia are the "professional" phagocytes of the CNS. Phagocytosis is crucial for normal CNS development and maintenance, but it can be either beneficial or detrimental after injury or disease. For instance, white matter damage releases myelin debris that must be cleared by microglia in order for re-myelination to occur. However, phagocytosis can also produce damaging reactive oxygen species (ROS). Furthermore, microglia can acquire pro-inflammatory (M1) or anti-inflammatory (M2) activation states that affect cell functions. Although microglia are exposed to a changing cytokine environment after injury or disease, little is known about the molecular and functional consequences. Therefore, we applied several microglial activation paradigms, with or without myelin debris

SUBMITTER: Siddiqui TA 

PROVIDER: S-EPMC4806433 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature