Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes.

ABSTRACT:

Background

Oxidative stress, inflammation and endothelial dysfunction are interrelated factors in the etiology of cardiovascular disease, but their linkage to type 2 diabetes is less clear. We examined the association of these biomarkers with incident type 2 diabetes (T2D).

Methods

Analysis of 2339 participants in the community-based coronary artery risk development in young adults (CARDIA) study. Participants (age 40.1 ± 3.6 years, 44 % Black, 58 % women) were free of diabetes, and were followed 10 years. Cox regression was used to estimate hazard ratios (HRs) for incident T2D adjusting for the other biomarkers under study, demographic and lifestyle measures, dietary biomarkers, BMI (kg/m(2)) and metabolic syndrome components.

Results

F2-isoprostanes and oxidized LDL

SUBMITTER: Odegaard AO 

PROVIDER: S-EPMC4806507 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature