Sinonasal epithelial cell response to Staphylococcus aureus burden in chronic rhinosinusitis.

ABSTRACT:

Importance

Chronic rhinosinusitis (CRS) is an inflammatory disorder of the nose and paranasal sinuses. Staphylococcus aureus is increasingly linked with CRS exacerbations. Little is known about how bacteria activate inflammatory pathways that contribute to CRS.

Objective

To develop an in vitro coculture system to explore how infection with S aureus stimulates innate immune responses of sinonasal epithelial cells (SNECs).

Design, setting, and participants

Sinonasal epithelial cells were collected from 13 patients during endoscopic sinus surgery and grown in culture at the air-liquid interface from July 2014 through December 2014.

Interventions

Differentiated SNECs from control individuals, patients with CRS with nasal polyps (CRSwNPs), and patients with CRS with

SUBMITTER: Kohanski MA 

PROVIDER: S-EPMC4806547 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature