Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation.

ABSTRACT: Amyloid-β, a hallmark of Alzheimer's disease, begins accumulating up to two decades before the onset of dementia, and can be detected in vivo applying amyloid-β positron emission tomography tracers such as carbon-11-labelled Pittsburgh compound-B. A variety of thresholds have been applied in the literature to define Pittsburgh compound-B positron emission tomography positivity, but the ability of these thresholds to detect early amyloid-β deposition is unknown, and validation studies comparing Pittsburgh compound-B thresholds to post-mortem amyloid burden are lacking. In this study we first derived thresholds for amyloid positron emission tomography positivity using Pittsburgh compound-B positron emission tomography in 154 cognitively normal older adults with four complementary approaches:

SUBMITTER: Villeneuve S 

PROVIDER: S-EPMC4806716 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature