Microevolution of Monophasic Salmonella Typhimurium during Epidemic, United Kingdom, 2005-2010.

ABSTRACT: Microevolution associated with emergence and expansion of new epidemic clones of bacterial pathogens holds the key to epidemiologic success. To determine microevolution associated with monophasic Salmonella Typhimurium during an epidemic, we performed comparative whole-genome sequencing and phylogenomic analysis of isolates from the United Kingdom and Italy during 2005-2012. These isolates formed a single clade distinct from recent monophasic epidemic clones previously described from North America and Spain. The UK monophasic epidemic clones showed a novel genomic island encoding resistance to heavy metals and a composite transposon encoding antimicrobial drug resistance genes not present in other Salmonella Typhimurium isolates, which may have contributed to epidemiologic success. A remar

SUBMITTER: Petrovska L 

PROVIDER: S-EPMC4806966 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature