Personalizing Aspirin Use for Targeted Breast Cancer Chemoprevention in Postmenopausal Women.

ABSTRACT:

Objective

To evaluate the association of aspirin and other nonsteroidal anti-inflammatory drugs with the incidence of postmenopausal breast cancer for risk subgroups defined by selected nonmodifiable or difficult to modify breast cancer risk factors in order to better understand the potential risk-benefit ratio for targeted chemoprevention.

Patients and methods

Postmenopausal women with no history of cancer on July 1, 1992 (N=26,580), were prospectively followed up through December 31, 2005, for breast cancer incidence (N=1581). Risk subgroups were defined on the basis of family history of breast cancer, age at menarche, age at menopause, parity/age at first live birth, personal history of benign breast disease, and body mass index. Hazard ratios (HRs) and 95% CIs adjusted f

SUBMITTER: Bardia A 

PROVIDER: S-EPMC4807132 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature