The transient dermal exposure II: post-exposure absorption and evaporation of volatile compounds.

ABSTRACT: The transient dermal exposure is one where the skin is exposed to chemical for a finite duration, after which the chemical is removed and no residue remains on the skin's surface. Chemical within the skin at the end of the exposure period can still enter the systemic circulation. If it has some volatility, a portion of it will evaporate from the surface before it has a chance to be absorbed by the body. The fate of this post-exposure "skin depot" is the focus of this theoretical study. Laplace domain solutions for concentration distribution, flux, and cumulative mass absorption and evaporation are presented, and time domain results are obtained through numerical inversion. The Final Value Theorem is applied to obtain the analytical solutions for the total fractional absorption by the body

SUBMITTER: Frasch HF 

PROVIDER: S-EPMC4807354 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature