Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries.

ABSTRACT:

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Infection with human cytomegalovirus (HCMV) profoundly affects cellular metabolism. Like in tumor cells, HCMV infection increases glycolysis, and glucose carbon is shifted from the mitochondrial tricarboxylic acid cycle to the biosynthesis of fatty acids. However, unlike in many tumor cells, where aerobic glycolysis is accompanied by suppression of mitochondrial oxidative phosphorylation, HCMV induces mitochondrial biogenesis and respiration. Here, we affinity purified mitochondria and used quantitative mass spectrometry to determine how the mitochondrial proteome changes upon HCMV infection. We found that the mitochondrial transcription and translation systems are induced early during the viral replication cycle. Specifically, proteins involved in biogenesis of the mito

SUBMITTER: Karniely S 

PROVIDER: S-EPMC4807356 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature