Features of Circulating Parainfluenza Virus Required for Growth in Human Airway.

ABSTRACT:

Unlabelled

Respiratory paramyxoviruses, including the highly prevalent human parainfluenza viruses, cause the majority of childhood croup, bronchiolitis, and pneumonia, yet there are currently no vaccines or effective treatments. Paramyxovirus research has relied on the study of laboratory-adapted strains of virus in immortalized cultured cell lines. We show that findings made in such systems about the receptor interaction and viral fusion requirements for entry and fitness-mediated by the receptor binding protein and the fusion protein-can be drastically different from the requirements for infection in vivo. Here we carried out whole-genome sequencing and genomic analysis of circulating human parainfluenza virus field strains to define functional and structural properties of prote

SUBMITTER: Palermo LM 

PROVIDER: S-EPMC4807361 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature