Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic Protein.

ABSTRACT:

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Urinary tract infection (UTI) is a disease of extremely high incidence in both community and nosocomial settings. UTIs cause significant morbidity and mortality, with approximately 150 million cases globally per year. Uropathogenic Escherichia coli (UPEC) is the primary cause of UTI and is generally treated empirically. However, the rapidly increasing incidence of UTIs caused by multidrug-resistant UPEC strains has led to limited available treatment options and highlights the urgent need to develop alternative treatment and prevention strategies. In this study, we performed a comprehensive analysis to define the regulation, structure, function, and immunogenicity of recently identified UPEC vaccine candidate C1275 (here referred to as IrmA). We showed that the irmA gene

SUBMITTER: Moriel DG 

PROVIDER: S-EPMC4807369 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature