Characterization of SlyA in Shigella flexneri Identifies a Novel Role in Virulence.

ABSTRACT: The SlyA transcriptional regulator has important roles in the virulence and pathogenesis of several members of the Enterobacteriaceae family, including Salmonella enterica serovar Typhimurium and Escherichia coli. Despite the identification of the slyA gene in Shigella flexneri nearly 2 decades ago, as well as the significant conservation of SlyA among enteric bacteria, the role of SlyA in Shigella remains unknown. The genes regulated by SlyA in closely related organisms often are absent from or mutated inS. flexneri, and consequently many described SlyA-dependent phenotypes are not present. By characterizing the expression of slyA and determining its ultimate effect in this highly virulent organism, we postulated that novel SlyA-regulated virulence phenotypes would be identified. In this

SUBMITTER: Weatherspoon-Griffin N 

PROVIDER: S-EPMC4807491 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature