¹H NMR Metabolomics Study of Spleen from C57BL/6 Mice Exposed to Gamma Radiation.

ABSTRACT: Due to the potential risk of accidental exposure to gamma radiation, it's critical to identify the biomarkers of radiation exposed creatures. In the present study, NMR based metabolomics combined with multivariate data analysis to evaluate the metabolites changed in the C57BL/6 mouse spleen after 4 days whole body exposure to 3.0 Gy and 7.8 Gy gamma radiations. Principal component analysis (PCA) and orthogonal projection to latent structures analysis (OPLS) are employed for classification and identification potential biomarkers associated with gamma irradiation. Two different strategies for NMR spectral data reduction (i.e., spectral binning and spectral deconvolution) are combined with normalize to constant sum and unit weight before multivariate data analysis, respectively. The combinati

SUBMITTER: Xiao X 

PROVIDER: S-EPMC4807627 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature