FTO genotype and weight loss in diet and lifestyle interventions: a systematic review and meta-analysis.

ABSTRACT:

Background

Studies have suggested that the fat mass and obesity-associated (FTO) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions, but results are inconsistent.

Objective

We aimed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions.

Design

A search of English-language articles in the PubMed and Embase databases (through 30 April 2015) was performed. Eligible studies were diet/lifestyle weight-loss intervention studies conducted in adults that reported changes in body weight or body mass index (BMI) by the FTO variant rs9939609 (or its proxy). Differences in weight loss between FTO genotypes across studies were poo

SUBMITTER: Xiang L 

PROVIDER: S-EPMC4807705 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature