Effect of ω-3 supplementation on placental lipid metabolism in overweight and obese women.

ABSTRACT:

Background

The placentas of obese women accumulate lipids that may alter fetal lipid exposure. The long-chain omega-3 fatty acids (n–3 FAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) alter FA metabolism in hepatocytes, although their effect on the placenta is poorly understood.

Objective

We aimed to investigate whether n–3 supplementation during pregnancy affects lipid metabolism in the placentas of overweight and obese women at term.

Design

A secondary analysis of a double-blind randomized controlled trial was conducted in healthy overweight and obese pregnant women who were randomly assigned to DHA plus EPA (2 g/d) or placebo twice a day from early pregnancy to term. Placental FA uptake, esterification, and oxidation pathways were studied by measurin

SUBMITTER: Calabuig-Navarro V 

PROVIDER: S-EPMC4807706 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature