Millimeter-scale epileptiform spike propagation patterns and their relationship to seizures.

ABSTRACT:

Objective

Current mapping of epileptic networks in patients prior to epilepsy surgery utilizes electrode arrays with sparse spatial sampling (∼1.0 cm inter-electrode spacing). Recent research demonstrates that sub-millimeter, cortical-column-scale domains have a role in seizure generation that may be clinically significant. We use high-resolution, active, flexible surface electrode arrays with 500 μm inter-electrode spacing to explore epileptiform local field potential (LFP) spike propagation patterns in two dimensions recorded from subdural micro-electrocorticographic signals in vivo in cat. In this study, we aimed to develop methods to quantitatively characterize the spatiotemporal dynamics of epileptiform activity at high-resolution.

Approach

We topically administered a G

SUBMITTER: Vanleer AC 

PROVIDER: S-EPMC4807853 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature