Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes.

ABSTRACT: Type 1 diabetes is a chronic autoimmune disease resulting from T cell-mediated destruction of insulin-producing beta cells within pancreatic islets. Disease incidence has increased significantly in the last two decades, especially in young children. Type 1 diabetes is now predictable in humans with the measurement of serum islet autoantibodies directed against insulin and beta cell proteins. Knowledge regarding the presentation of insulin and islet antigens to T cells has increased dramatically over the last several years. Here, we review the trimolecular complex in diabetes, which consists of a major histocompatibility molecule,self-peptide, and T cell receptor, with a focus on insulin peptide presentation to T cells. With this increased understanding of how antigens are presented to T ce

SUBMITTER: Nakayama M 

PROVIDER: S-EPMC4807868 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature