Replication Study of Polymorphisms Associated With Brain Arteriovenous Malformation in a Population From South of Brazil.

ABSTRACT:

Introduction

The aim of this study was to reproducibly determine if any of the polymorphisms were associated with the susceptibility to brain arteriovenous malformations (BAVM) or the risk of intracranial hemorrhage (ICH) presentation.

Methods

We recruited 63 BAVM patients and 96 controls. The polymorphisms selected for evaluation were apolipoprotein E (APOE), tumor necrosis factor alpha (TNF 238G>A - rs361525), interleukin 1 beta (IL1B 511C>T - rs16944 and IL1B -31T>C - rs1143627), activin-like kinase 1 (ACVRL1 IVS3-35A>G - rs2071219), endoglin (ENG 207G>A - rs11545664), and interleukin 6 (IL6 174G>C - rs1800795).

Results

In the single analysis, we observed statistically significant differences in the allele distributions for IL1B -31T>C (rs1143627) between the BAVM p

SUBMITTER: Franciscatto AC 

PROVIDER: S-EPMC4807924 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature