Ontology highlight
ABSTRACT:
SUBMITTER: Molto J
PROVIDER: S-EPMC4808213 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20160325 4
Data on dolutegravir removal by hemodialysis are lacking. To study this, we measured dolutegravir plasma concentrations in samples of blood entering and leaving the dialyzer and of the resulting dialysate from 5 HIV-infected patients with end-stage renal disease. The median dolutegravir hemodialysis extraction ratio was 7%. The dolutegravir concentrations after the dialysis session remained far above the protein-binding-adjusted inhibitory concentration. Our results show minimal dolutegravir rem ...[more]