Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning.

ABSTRACT: Intranasal delivery is an emerging method for bypassing the blood brain barrier (BBB) and targeting therapeutics to the CNS. Oximes are used to counteract the effects of organophosphate poisoning, but they do not readily cross the BBB. Therefore, they cannot effectively counteract the central neuropathologies caused by cholinergic over-activation when administered peripherally. For these reasons we examined intranasal administration of oximes in an animal model of severe organophosphate poisoning to determine their effectiveness in reducing mortality and seizure-induced neuronal degeneration. Using the paraoxon model of organophosphate poisoning, we administered the standard treatment (intramuscular pralidoxime plus atropine sulphate) to all animals and then compared the effectiveness of i

SUBMITTER: Krishnan JKS 

PROVIDER: S-EPMC4808345 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature