Impact of interventions to reduce Alzheimer's disease pathology on the prevalence of dementia in the oldest-old.

ABSTRACT:

Introduction

The number of persons aged >90 years will grow significantly in coming decades. This group has the highest rates of dementia, most commonly Alzheimer's disease (AD).

Methods

Using The 90+ Study, we developed a statistical model for dementia risk based on brain pathologies. Intervention scenarios which reduce or eliminate AD pathology were considered, and the numbers of dementia cases among the U.S. oldest-old that could be prevented were estimated.

Results

The U.S. dementia prevalence among the oldest-old will increase from 1.35 million in 2015 to 4.72 million in 2050. If interventions eliminate AD pathology, dementia prevalence would be reduced by approximately 50%, averting nearly 2.4 million cases in 2050. However, large numbers of dementia cases would

SUBMITTER: Brookmeyer R 

PROVIDER: S-EPMC4808364 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature