Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits.

ABSTRACT: Animals generate movement by engaging spinal circuits that direct precise sequences of muscle contraction, but the identity and organizational logic of local interneurons that lie at the core of these circuits remain unresolved. Here, we show that V1 interneurons, a major inhibitory population that controls motor output, fractionate into highly diverse subsets on the basis of the expression of 19 transcription factors. Transcriptionally defined V1 subsets exhibit distinct physiological signatures and highly structured spatial distributions with mediolateral and dorsoventral positional biases. These positional distinctions constrain patterns of input from sensory and motor neurons and, as such, suggest that interneuron position is a determinant of microcircuit organization. Moreover, V1 div

SUBMITTER: Bikoff JB 

PROVIDER: S-EPMC4808435 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature