Nrf2--a therapeutic target for the treatment of neurodegenerative diseases.

ABSTRACT: The brain is very sensitive to changes in redox status; thus maintaining redox homeostasis in the brain is critical for the prevention of accumulating oxidative damage. Aging is the primary risk factor for developing neurodegenerative diseases. In addition to age, genetic and environmental risk factors have also been associated with disease development. The primary reactive insults associated with the aging process are a result of oxidative stress (OS) and nitrosative stress (NS). Markers of increased oxidative stress, protein and DNA modification, inflammation, and dysfunctional proteostasis have all been implicated in contributing to the progression of neurodegeneration. The ability of the cell to combat OS/NS and maintain a clearance mechanism for misfolded aggregating proteins determin

SUBMITTER: Johnson DA 

PROVIDER: S-EPMC4809057 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature