Ontology highlight
ABSTRACT:
SUBMITTER: Park JH
PROVIDER: S-EPMC4809061 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Cell reports 20160225 9
Transmitochondrial cybrids and multiple OMICs approaches were used to understand mitochondrial reprogramming and mitochondria-regulated cancer pathways in triple-negative breast cancer (TNBC). Analysis of cybrids and established breast cancer (BC) cell lines showed that metastatic TNBC maintains high levels of ATP through fatty acid β oxidation (FAO) and activates Src oncoprotein through autophosphorylation at Y419. Manipulation of FAO including the knocking down of carnitine palmitoyltransferas ...[more]