Ontology highlight
ABSTRACT:
SUBMITTER: Hakimi AA
PROVIDER: S-EPMC4809063 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Cancer cell 20160101 1
Dysregulated metabolism is a hallmark of cancer, manifested through alterations in metabolites. We performed metabolomic profiling on 138 matched clear cell renal cell carcinoma (ccRCC)/normal tissue pairs and found that ccRCC is characterized by broad shifts in central carbon metabolism, one-carbon metabolism, and antioxidant response. Tumor progression and metastasis were associated with metabolite increases in glutathione and cysteine/methionine metabolism pathways. We develop an analytic pip ...[more]