Genome-wide association study of new-onset atrial fibrillation after coronary artery bypass grafting surgery.

ABSTRACT:

Background

Postoperative atrial fibrillation (AF) is a potentially life-threatening complication after coronary artery bypass graft (CABG) surgery. Genetic predisposition may predict risk for developing postoperative AF.

Methods

Study subjects underwent CABG surgery with cardiopulmonary bypass at Duke University Medical Center. In a discovery cohort of 877 individuals from the Perioperative Genetics and Safety Outcomes Study, we performed a genome-wide association study using a logistic regression model with a covariate adjustment for AF risk index. Single-nucleotide polymorphisms (SNPs) that met a P < 5 × 10(-5) were further tested using a replication dataset of 304 individuals from the CATHeterization GENetics biorepository, followed by meta-analysis. Potential pathways re

SUBMITTER: Kertai MD 

PROVIDER: S-EPMC4809141 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature