A High Throughput Method for Estimating Mouth-Level Intake of Mainstream Cigarette Smoke.

ABSTRACT:

Introduction

We developed a high throughput method for estimating smoker's mainstream smoke intake on a per-cigarette basis by analyzing discarded cigarette butts. This new method utilizes ultraviolet/visible (UV-Vis) spectrophotometric analysis of isopropanol-soluble smoke particulate matter extracted from discarded cigarette filters.

Methods

When measured under a wide range of smoking conditions for a given brand variant, smoking machine delivery of nicotine, benzene, polycyclic aromatic hydrocarbons, and tobacco-specific nitrosamines can be related to the overall filter extract absorbance at 360 nm. Once this relationship has been established, UV-Vis analysis of a discarded cigarette filter butt gives a quantitative measure of a smoker's exposure to these analytes.

Res

SUBMITTER: Yan X 

PROVIDER: S-EPMC4809385 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature