Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding.

ABSTRACT:

Objective

We investigated the association between apoE protein plasma levels and brain amyloidosis and the effect of the top 10 Alzheimer disease (AD) risk genes on this association.

Methods

Our dataset consisted of 18 AD, 52 mild cognitive impairment, and 3 cognitively normal Alzheimer's Disease Neuroimaging Initiative 1 (ADNI1) participants with available [(11)C]-Pittsburgh compound B (PiB) and peripheral blood protein data. We used cortical pattern matching to study associations between plasma apoE and cortical PiB binding and the effect of carrier status for the top 10 AD risk genes.

Results

Low plasma apoE was significantly associated with high PiB SUVR, except in the sensorimotor and entorhinal cortex. For BIN1 rs744373, the association was observed only in mino

SUBMITTER: Lazaris A 

PROVIDER: S-EPMC4809461 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature