Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice.

ABSTRACT:

Rationale

Chemotherapy-induced cognitive impairment, also known as 'chemobrain', is now widely recognized as a frequent adverse side effect of cancer treatment that often persists into survivorship. There are no drugs available to prevent or treat chemotherapy-induced cognitive deficits. The aim of this study was to establish a mouse model of cisplatin-induced cognitive deficits and to determine the potential preventive effects of the anti-diabetic drug metformin.

Results

Treatment of C57/BL6J mice with cisplatin (cumulative dose 34.5 mg/kg) impaired performance in the novel object and place recognition task as well as in the social discrimination task indicating cognitive deficits. Co-administration of metformin prevented these cisplatin-induced cognitive impairments. At th

SUBMITTER: Zhou W 

PROVIDER: S-EPMC4809545 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature