Bayesian Group Sequential Clinical Trial Design using Total Toxicity Burden and Progression-Free Survival.

ABSTRACT: Delivering radiation to eradicate a solid tumor while minimizing damage to nearby critical organs remains a challenge. For esophageal cancer, radiation therapy may damage the heart or lungs, and several qualitatively different, possibly recurrent toxicities associated with chemoradiation or surgery may occur, each at two or more possible grades. In this article, we describe a Bayesian group sequential clinical trial design, based on total toxicity burden (TTB) and progression-free survival duration, for comparing two radiation therapy modalities for esophageal cancer. Each patient's toxicities are modeled as a multivariate doubly stochastic Poisson point process, with marks identifying toxicity grades. Each grade of each type of toxicity is assigned a severity weight, elicited from clinica

SUBMITTER: Hobbs BP 

PROVIDER: S-EPMC4809549 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature