Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia.

ABSTRACT:

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The incidence of nonalcoholic fatty liver disease (NAFLD) and hyperlipidemia, with their associated risks of endstage liver and cardiovascular diseases, is increasing rapidly due to the prevalence of obesity. Although the mechanisms of NAFLD have been studied extensively, the underlying pathogenesis and the role of microRNAs in this process remain relatively unclear. MicroRNA (miRNA)-dependent posttranscriptional gene silencing is now recognized as a key element of lipid metabolism. Here we report that the expression of microRNA-24 (miR-24) is significantly increased in the livers of high-fat diet-treated mice and in isolated human hepatocytes incubated with fatty acid. Knockdown of miR-24 in those mice caused impaired hepatic lipid accumulation and reduced plasma trigly

SUBMITTER: Ng R 

PROVIDER: S-EPMC4809671 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature