From Conventional to Next Generation Sequencing of Epstein-Barr Virus Genomes.

ABSTRACT: Genomic sequences of Epstein-Barr virus (EBV) have been of interest because the virus is associated with cancers, such as nasopharyngeal carcinoma, and conditions such as infectious mononucleosis. The progress of whole-genome EBV sequencing has been limited by the inefficiency and cost of the first-generation sequencing technology. With the advancement of next-generation sequencing (NGS) and target enrichment strategies, increasing number of EBV genomes has been published. These genomes were sequenced using different approaches, either with or without EBV DNA enrichment. This review provides an overview of the EBV genomes published to date, and a description of the sequencing technology and bioinformatic analyses employed in generating these sequences. We further explored ways through whic

SUBMITTER: Kwok H 

PROVIDER: S-EPMC4810250 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature