Cellular microRNAs Repress Vesicular Stomatitis Virus but Not Theiler's Virus Replication.

ABSTRACT: Picornavirus' genomic RNA is a positive-stranded RNA sequence that also serves as a template for translation and replication. Cellular microRNAs were reported to interfere to different extents with the replication of specific picornaviruses, mostly acting as inhibitors. However, owing to the high error rate of their RNA-dependent RNA-polymerases, picornavirus quasi-species are expected to evolve rapidly in order to lose any detrimental microRNA target sequence. We examined the genome of Theiler's murine encephalomyelitis virus (TMEV) for the presence of under-represented microRNA target sequences that could have been selected against during virus evolution. However, little evidence for such sequences was found in the genome of TMEV and introduction of the most under-represented microRNA ta

SUBMITTER: De Cock A 

PROVIDER: S-EPMC4810265 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature