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SPOC: a widely distributed domain associated with cancer, apoptosis and transcription.

ABSTRACT:

Background

The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level.

Results

We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches and structural prediction methods.

Conclusions

The widely distributed DIO (Death inducer-obliterator) family is related to cancer and apoptosis and offers new clues about SPOC domain functionality.

SUBMITTER: Sanchez-Pulido L

PROVIDER: S-EPMC481055 | biostudies-literature | 2004 Jul

REPOSITORIES: biostudies-literature

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Publications

SPOC: a widely distributed domain associated with cancer, apoptosis and transcription.

Sánchez-Pulido Luis L Rojas Ana M AM van Wely Karel H KH Martinez-A Carlos C Valencia Alfonso A

BMC bioinformatics 20040707

<h4>Background</h4>The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level.<h4>Results</h4>We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches ...[more]

PMID: 15239844

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