Defining the Microglia Response during the Time Course of Chronic Neurodegeneration.

ABSTRACT:

Unlabelled

Inflammation has been proposed as a major component of neurodegenerative diseases, although the precise role it plays has yet to be defined. We examined the role of key contributors to this inflammatory process, microglia, the major resident immune cell population of the brain, in a prion disease model of chronic neurodegeneration. Initially, we performed an extensive reanalysis of a large study of prion disease, where the transcriptome of mouse brains had been monitored throughout the time course of disease. Our analysis has provided a detailed classification of the disease-associated genes based on cell type of origin and gene function. This revealed that the genes upregulated during disease, regardless of the strain of mouse or prion protein, are expressed predominant

SUBMITTER: Vincenti JE 

PROVIDER: S-EPMC4810622 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature