Regulation of Norovirus Virulence by the VP1 Protruding Domain Correlates with B Cell Infection Efficiency.

ABSTRACT:

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Human noroviruses are a leading cause of gastroenteritis across the globe, but the pathogenic mechanisms responsible for disease are not well established. The availability of a murine norovirus model system provides the opportunity to elucidate viral and host determinants of virulence in a natural host. For example, previous studies have revealed that the protruding domain of the murine norovirus capsid protein VP1, specifically residue 296 of VP1, regulates virulent infection. We identified a panel of nonsynonymous mutations in the open reading frame 2 (ORF2) gene encoding VP1 that arose in persistently infected mice and tested whether these mutations conferred phenotypic changes to viral replication and virulence. Consistent with previous studies, we demonstrate that a

SUBMITTER: Zhu S 

PROVIDER: S-EPMC4810633 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature