Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway.

ABSTRACT:

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The cellular response to virus infection is initiated when pathogen recognition receptors (PRR) engage viral pathogen-associated molecular patterns (PAMPs). This process results in induction of downstream signaling pathways that activate the transcription factor interferon regulatory factor 3 (IRF3). IRF3 plays a critical role in antiviral immunity to drive the expression of innate immune response genes, including those encoding antiviral factors, type 1 interferon, and immune modulatory cytokines, that act in concert to restrict virus replication. Thus, small molecule agonists that can promote IRF3 activation and induce innate immune gene expression could serve as antivirals to induce tissue-wide innate immunity for effective control of virus infection. We identified sm

SUBMITTER: Pattabhi S 

PROVIDER: S-EPMC4810700 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature