Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder.

ABSTRACT:

Background

Recent meta-analyses of resting-state networks in major depressive disorder (MDD) implicate network disruptions underlying cognitive and affective features of illness. Heterogeneity of findings to date may stem from the relative lack of data parsing clinical features of MDD such as phase of illness and the burden of multiple episodes.

Method

Resting-state functional magnetic resonance imaging data were collected from 17 active MDD and 34 remitted MDD patients, and 26 healthy controls (HCs) across two sites. Participants were medication-free and further subdivided into those with single v. multiple episodes to examine disease burden. Seed-based connectivity using the posterior cingulate cortex (PCC) seed to probe the default mode network as well as the amygdala and

SUBMITTER: Jacobs RH 

PROVIDER: S-EPMC4810773 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature