Dramatyping: a generic algorithm for detecting reasonable temporal correlations between drug administration and lab value alterations.

ABSTRACT: According to the World Health Organization, one of the criteria for the standardized assessment of case causality in adverse drug reactions is the temporal relationship between the intake of a drug and the occurrence of a reaction or a laboratory test abnormality. This article presents and describes an algorithm for the detection of a reasonable temporal correlation between the administration of a drug and the alteration of a laboratory value course. The algorithm is designed to process normalized lab values and is therefore universally applicable. It has a sensitivity of 0.932 for the detection of lab value courses that show changes in temporal correlation with the administration of a drug and it has a specificity of 0.967 for the detection of lab value courses that show no changes. There

SUBMITTER: Newe A 

PROVIDER: S-EPMC4811173 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature