Cases of Psychiatric Morbidity in Pediatric Patients After Remission of Cushing Syndrome.

ABSTRACT: Endogenous Cushing syndrome (CS) may have different effects in children than what has been described in adults. Previous studies of children and adolescents with CS have identified cognitive decline despite reversal of brain atrophy after remission of CS. Although the observations of parents of children and adolescents with CS support personality changes, significant psychopathology has not been described in the literature. We report 9 children who underwent successful surgery (transsphenoidal surgery [TSS] or resection of bronchial carcinoid) for treatment of CS and subsequently developed significant affective pathology. Affective symptoms included anger-rage outbursts, suicidal ideation, irritability, anxiety, and depression. One child, who committed suicide 60 months after TSS, had rece

SUBMITTER: Keil MF 

PROVIDER: S-EPMC4811308 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature